Round 1

Clinical Demonstration Projects


Lung Cancer Project

purchase - Lung Cancer - Image 1.jpg

The lung cancer research project will pilot the use, and assess the impact, of genomic testing in lung cancer treatment in Queensland. The project team will work with lung cancer patients across Queensland, including sub studies involving indigenous patients from metropolitan, regional and remote communities.

The approaches used in the lung cancer project could be applied across other cancer types in the future.

Deliverables

Patient Recruitment and Testing:

  • Meet with lung cancer multidisciplinary teams to define patients who should be offered medical genomics services

  • Develop and test protocols for sample collection and transfer to ATGC

  • Collect and share samples between MGHA, ATGC

  • Perform WES/panel sequencing

  • Optimise approach depending on observed performance

Data Analysis, Transfer and Reporting Approaches:

  • Investigate infrastructure and personnel availability and requirements for linking ATGC, JCU and AGHA

  • Meet with lung cancer MDTs to develop optimal report structures

  • Implement data transfer and analysis and reporting pipelines at involved analysis and clinical sites

  • Establish genomics database with EMR linkage

  • Optimise analytic and reporting approaches after discussion with end-users

Health Economics Assessment Infrastructure:

  • Meet with MGHA/AGHA to harmonise cost-effectiveness analysis approaches

  • Establish data linkage methods with QCCAT

  • Implement and capture cost and health economic outcome data at PCH, PAH and region sites

  • Provide analysed cost-benefit data to enable optimisation of models of care

Consent / Education & Consent:

  • Develop agreed text for clinical and research consent for non- Indigenous lung cancer patients

  • Develop agreed text for clinical and research consent for Indigenous lung cancer patients

  • Produce videos for informed consent process

  • Measure performance and acceptability of smart-phone enabled consenting process, adjust approach

  • Contribute units to HGSA educational programs in lung cancer genomics

Medical Genomics Ethics and Policy:

  • Hold workshops on genomic non-discrimination

  • Hold workshops and community meetings regarding Indigenous genomics

  • Write policy documents and publicise

  • Adapt medical genomics services in light of Indigenous meeting outcomes

  • Meet with State Government to lobby for genomic non- discrimination recommendations

Project Investigators

  • Lead - Professor Matt Brown, PAH and QUT

  • Professor Kenneth O’Byrne, QUT

  • Professor Nick Graves, QUT

  • Associate Professor Paul Leo, QUT

  • Dr Stephen Ayre, PAH

  • Professor Kwun Fong, UQ & TPCH

  • Professor Ian Yang, UQ & TPCH

  • Professor John Devereux, UQ

  • Dr John Rowell, PQ

  • Professor Stephen Fox, PMCC

  • Dr Jayesh Desai, PMCC

  • Professor Jacinta Elston, JCU

  • Professor Alan Baxter, JCU

  • Professor Sabe Sabesan, JCU

  • Dr Emily Callander, JCU

Lung Cancer Project Factsheet [pdf]